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  • Title: [Predicative value of 99mTc-MIBI scintimammography in neoadjuvant chemotherapeutic effect of patients with operable breast cancer].
    Author: Liu ZZ, Lu ZD, Liu H, Li LF, Zhang HW, Yang H, Li WL, Cui SD.
    Journal: Zhonghua Yi Xue Za Zhi; 2011 Feb 15; 91(6):382-4. PubMed ID: 21418909.
    Abstract:
    OBJECTIVE: To evaluate the relationship between the clearance rate of technetium-99m methoxyisobutylisonitrile ((99m)Tc-MIBI) in scintimammography and the efficacy of neoadjuvant chemotherapy (NCT) of patients with operable breast cancer. METHODS: Seventy-eight patients with breast cancer underwent (99m)Tc-MIBI scintimammography at pre-NCT. And static planar images were taken at 10 min and 180 min post-scintimammography. The clearance rate was calculated in each patient. And the efficacy of NCT was evaluated after 2 cycles. RESULTS: The clearance rates of patients with a poor or good efficacy of chemotherapy were 24.21% ± 6.38% (n = 14) and 14.13% ± 5.98% (n = 64) respectively. There was significant difference between two groups. And a significant correlation was observed between the efficacy of chemotherapy and the clearance rate of (99m)Tc-MIBI (r = -0.539, P < 0.001). CONCLUSION: The scintimammography of (99m)Tc-MIBI may be employed to evaluate the efficacy of NCT.
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