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  • Title: Slow hyperpolarizing action of tryptamine on myenteric neurons of the isolated guinea-pig ileum.
    Author: Takaki M, Mizutani M, Jin JG, Nakayama S.
    Journal: Acta Med Okayama; 1990 Apr; 44(2):87-91. PubMed ID: 2141967.
    Abstract:
    In the present study, tryptamine produced a slow hyperpolarization in a few neurons other than a slow depolarization in myenteric neurons of the isolated guinea-pig ileum. Neither the adrenergic neuron blocker, guanethidine nor the 5-hydroxytryptamine uptake inhibitor, zimelidine, which can inhibit the release of 5-hydroxytryptamine from enteric neurites induced by tryptamine (M. Takaki et al. (1985) Neuroscience 16, 223-240), affected this slow hyperpolarization. Therefore, it was concluded that the slow hyperpolarization induced by tryptamine in myenteric neurons was not mediated via the release of 5-hydroxytryptamine or noradrenaline. It might be possible that the hyperpolarization was induced by a direct action of tryptamine on myenteric neurons per se.
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