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  • Title: Maternal and child's vitamin D supplement use and vitamin D level in relation to childhood lung function: the KOALA Birth Cohort Study.
    Author: Cremers E, Thijs C, Penders J, Jansen E, Mommers M.
    Journal: Thorax; 2011 Jun; 66(6):474-80. PubMed ID: 21422038.
    Abstract:
    BACKGROUND: Vitamin D is associated with lung function in adults, but its relation with childhood lung function is still unclear. OBJECTIVE: To investigate whether prenatal and postnatal vitamin D supplementation and plasma level is associated with childhood lung function. METHODS: In the KOALA Birth Cohort Study, children's lung function (n=436) was measured at age 6-7 years by means of spirometry and presented as forced expiratory volume in 1 s (FEV1) z scores and forced vital capacity z scores. The mother and child's 25-hydroxyvitamin D plasma level was determined around 36 weeks of pregnancy and at age 2 years. Vitamin D supplement intake during pregnancy was defined based on the amount of vitamin D in supplements, and trimester and duration of use. Data on child's vitamin D supplement use were collected through questionnaires at ages 1, 2 and 6-7 years. RESULTS: 25-Hydroxyvitamin D level and vitamin D supplement use in childhood were not associated with lung function. Maternal use of vitamin D at ≤10 μg/day (adjusted beta (AdjB -0.37; 95% CI -0.69 to -0.05)), vitamin D containing multivitamin use in the second and/or third trimester (AdjB -0.26; 95% CI -0.49 to -0.03), and use for two trimesters (AdjB -0.25; 95% CI -0.49 to -0.02) were associated with a significantly lower FEV1 z score compared with no supplements. Maternal use of vitamin D at ≥10 μg/day and use in the first or all trimesters was not associated with significantly lower lung function levels. CONCLUSION: The authors found no association between 25-hydroxyvitamin D levels, vitamin D supplementation in childhood or recommended vitamin D dosage of ≥10 μg/day during pregnancy and lung function in children aged 6-7 years.
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