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  • Title: Kaposi's sarcoma following immunosuppressive therapy for vasculitis.
    Author: Bouattar T, Kazmouhi L, Alhamany Z, Beqqal K, Haffane L, Houssaini TS, Rhou H, Benamar L, Senouci K, Bayahia R, Ouzeddoun N.
    Journal: Saudi J Kidney Dis Transpl; 2011 Mar; 22(2):319-23. PubMed ID: 21422634.
    Abstract:
    Kaposi's sarcoma (KS) is widely reported to develop after renal transplantation and is induced by activation of a latent human herpes virus 8. We report the clinical features and outcome of a 50-year-old woman who presented with KS 18 weeks after starting immunosuppressive therapy for vasculitis. She had positive-titer IgG antibody to human herpes virus 8. Cyclophosphamide pulses were interrupted, and prednisone was decreased gradually to 10 mg/day. Skin lesions showed important regression with stabilization of the general state and renal function. Eight months later, the patient presented with a diffuse cutaneous KS that required the discontinuation of steroids. Within 1 month, her general status and renal function deteriorated, and she died with a disseminated intravascular coagulation syndrome.
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