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  • Title: Increasing synthetic efficiency via direct C-H functionalization: formal synthesis of an inhibitor of botulinum neurotoxin.
    Author: Potavathri S, Kantak A, DeBoef B.
    Journal: Chem Commun (Camb); 2011 Apr 28; 47(16):4679-81. PubMed ID: 21423956.
    Abstract:
    A new and efficient scheme for the synthesis of one of the best known inhibitors of botulinum neurotoxin serotype A (BoNTA) is reported herein. The synthetic route involves two palladium-catalyzed C-H functionalization reactions, formally activating three C-H bonds.
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