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  • Title: [Antimicrobial susceptibility of clinical isolates of aerobic Gram-negative bacteria in 2006].
    Author: Yoshida I, Yamaguchi T, Itoh Y, Tachibana M, Takahashi C, Kaku M, Kanemitsu K, Okada M, Horikawa Y, Shiotani J, Kino H, Ono Y, Baba H, Matsuo S, Asari S, Toyokawa M, Matsuoka K, Kusano N, Nose M, Murase M, Miyamoto H, Saikawa T, Hiramatsu K, Kohno S, Yanagihara K, Yamane N, Nakasone I, Maki H, Yamano Y.
    Journal: Jpn J Antibiot; 2010 Dec; 63(6):457-79. PubMed ID: 21425597.
    Abstract:
    We determined MICs of antibacterial agents against 1280 clinical strains of aerobic Gram-negative bacteria (19 genus or species) isolated at 16 Japanese facilities in 2006. MICs were determined using mostly broth microdilution method and antibacterial activity was assessed. Strains producing extended-spectrum beta-lactamases (ESBL) accounted for 3.7% of Escherichia coli, 2.7% of Klebsiella spp., and 11.4% of Proteus spp. Notably, 18.8% of Proteus mirabilis was found to produce ESBL higher than 16.7% in 2004. This result was higher extremely than other species. Among Haemophilus influenzae, only 1.2% produced beta-lactamase and 62.8% that increased compared with 57.7% in 2004, were beta-lactamase-negative ampicillin-resistant strains when classified by penicillin-binding protein 3 mutation. Although few antibacterial agents against Pseudomonas aeruginosa have potent activity, only three agents--doripenem, ciprofloxacin, and tobramycin-showed an MIC90 of 4 microg/mL. Of all P aeruginosa strains, 5.7% were resistant to six or more agents of nine antipseudomonal agents, a decrease compared to 8.7% in 2004. Against other glucose-non-fermentative Gram-negative bacteria, the activity of most antibacterial agents was similar to that in 2004.
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