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  • Title: Isolation and structural elucidation of proline-containing cyclopentapeptides from an endolichenic Xylaria sp.
    Author: Wu W, Dai H, Bao L, Ren B, Lu J, Luo Y, Guo L, Zhang L, Liu H.
    Journal: J Nat Prod; 2011 May 27; 74(5):1303-8. PubMed ID: 21428374.
    Abstract:
    Two new cyclic pentapeptides (1 and 2) and the known blazein (3), ganodesterone (4), ergosterin (5), cerevisterol (6), 24-methylcholesta-4,6,8(14),22-tetraen-3-one (7), 5,8-epidioxyergosta-6,22-dien-3-ol (8), 16-α-d-mannopyranosyloxyisopimar-7-en-19-oic acid (9), and 16-hydroxy isopimar-7-en-19-oic acid (10) have been isolated from the crude extract of an endolichenic Xylaria sp. The structures of 1 and 2 were elucidated primarily by NMR and MS methods. The absolute configurations of 1 and 2 were assigned using Marfey's method on their acid hydrolysate. Compounds 1-10 were evaluated for activity against fungi and for synergistic antifungal activity. Compound 1 showed synergistic antifungal activity against Candida albicans SC5314 with 0.004 μg/mL ketoconazole.
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