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  • Title: Effects of risperidone on learning and memory in naive and MK-801-treated rats.
    Author: Celikyurt IK, Akar FY, Ulak G, Mutlu O, Erden F.
    Journal: Pharmacology; 2011; 87(3-4):187-94. PubMed ID: 21430408.
    Abstract:
    BACKGROUND/AIMS: The aim of this study was to investigate the effects of an atypical antipsychotic risperidone (RIS; 0.06, 0.125 or 0.25 mg/kg, intraperitoneal, i.p.) on learning and memory processes, both in naive and MK-801-treated (0.15 mg/kg, i.p.) rats. METHODS: Modified elevated plus maze (mEPM), passive avoidance (PA) and Morris water maze (MWM) tasks were used. RESULTS: In the mEPM test, RIS (0.125 or 0.25 mg/kg) significantly decreased the transfer latency and reversed MK-801-induced prolongation in the transfer latency of rats on the 2nd day. In the PA test, RIS (0.125 or 0.25 mg/kg) slightly decreased step-through latency (retention latency) but this finding did not reach statistical significance in naive rats. RIS had no effect on MK-801-induced reduction of retention latency. In the MWM test, RIS (0.06, 0.125 or 0.25 mg/kg, i.p.) neither affected the time spent in the escape platform quadrant, nor the distance to the platform in naive rats. It (0.125 mg/kg) tended to increase MK-801-induced reduction of time spent in the escape platform quadrant, but this finding was insignificant. RIS (0.125 mg/kg) significantly shortened MK-801-induced elongation in the distance to the platform. RIS had no effect on the swimming speed of the animals. CONCLUSION: RIS might be effective in treating cognitive dysfunctions associated with schizophrenia.
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