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  • Title: [Blood levels of opioid peptides and alpha interferon under the action of dipyridamole].
    Author: Balashov AM, Surkina ID, Gotovtseva EP, Petrichenko OB, Panchenko LF.
    Journal: Biull Eksp Biol Med; 1990 May; 109(5):462-4. PubMed ID: 2143090.
    Abstract:
    The levels of met-enkephalin (ME), beta-endorphin (BE), and alpha-interferon (a-IFN) have been determined in the human blood 1 day after dipyridamole administration. Dipyridamole led to an increase in serum a-IFN concentration up to 3 times, and to simultaneous rise of the lymphocytes ability to produce a-IFN. The content of BE did not depend on dipyridamole treatment, but ME level achieved 110 +/- 4.8 pg/ml (compare to 79.5 +/- 7.6 pg/ml in control). Positive interrelation has been found out between individual ME concentrations and lymphocyte abilities to a-IFN production with the coefficient of correlation equal to 0.69. The effect of dipyridamole on ME level is suggested to develop via a-IFN interaction with the opioid systems.
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