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  • Title: Benzothiazole-substituted benzofuroquinolinium dye: a selective switch-on fluorescent probe for G-quadruplex.
    Author: Lu YJ, Yan SC, Chan FY, Zou L, Chung WH, Wong WL, Qiu B, Sun N, Chan PH, Huang ZS, Gu LQ, Wong KY.
    Journal: Chem Commun (Camb); 2011 May 07; 47(17):4971-3. PubMed ID: 21431154.
    Abstract:
    A new switch-on fluorescent probe containing the natural product cryptolepine analogue benzofuroquinolinium moiety (binding scaffold) and a benzothiazole moiety (signalling unit) shows a remarkable fluorescence enhancement selective for the G-quadruplex nucleic acid structure. Binding studies revealed that the highly selective response of the fluorescent probe arises from end-stack binding to G-quadruplex.
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