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  • Title: [Correlation between protein kinase C and differentiation of HL-60 cells induced by DMSO].
    Author: Wang L.
    Journal: Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 1990 Apr; 12(2):96-100. PubMed ID: 2143121.
    Abstract:
    Treatment of HL-60 cells with DMSO caused cells to differentiate along the myeloid way and 84% of the cells showed a reduction in NBT after 120h. Protein kinase C activity increased of during differentiation. It would reach 2.7 times that of the control after 72h in the presence of DMSO. The increase of protein kinase C activity was traced to the cytosolic rather than the membrane fraction. Chelator EGTA was necessary to extract protein kinase C. DMSO itself could not enhance protein kinase C activity, indicating that the effect of DMSO was indirect. All of these results showed that the activation of protein kinase C is important in the differentiation of HL-60 cells.
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