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  • Title: Detection of small RNAs and microRNAs using deep sequencing technology.
    Author: Havecker ER.
    Journal: Methods Mol Biol; 2011; 732():55-68. PubMed ID: 21431705.
    Abstract:
    Small RNAs (sRNAs) have made a large impact on many recent scientific discoveries. MicroRNAs (miRNAs) are a type of sRNA molecule and, although usually just 20-22 nucleotides in length, they are potent regulators of gene expression. Therefore, identification of miRNAs and profiling their abundance are fundamental to understanding an organism's or tissue's gene regulatory network. Next-generation sequencing methods have allowed researchers to quickly sequence and profile sRNA populations. This chapter describes a cloning procedure to identify the sRNAs or miRNAs present in an RNA sample.
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