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  • Title: Synthesis and evaluation of antibacterial activities of 5,7-dihydroxycoumarin derivatives.
    Author: Chin YP, Huang WJ, Hsu FL, Lin YL, Lin MH.
    Journal: Arch Pharm (Weinheim); 2011 Jun; 344(6):386-93. PubMed ID: 21433055.
    Abstract:
    This study examines the synthesis and antibacterial activities of 5,7-dihydroxycoumarin derivatives, whose structures were confirmed using analytical and spectral data. Twenty compounds were tested for their antibacterial activities against five microbial species such as E. coli, S. aureus, K. pneumonia, P. aeruginosa, and S. typhimurium were studied. Compounds 5 and 12 exhibited the most potent activity against Staphylococcus aureus with a MIC value of 2.5 µg/mL for each of the compounds.
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