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  • Title: [Changes on neurobehavioral development of the offspring in rats prenataly exposed by phenethyl isothiocyanate].
    Author: Zhi Y, Liu H, Geng G, Yu Z, Xu H.
    Journal: Wei Sheng Yan Jiu; 2011 Jan; 40(1):36-9, 42. PubMed ID: 21434308.
    Abstract:
    OBJECTIVE: To study the effect of rats prenatal exposed to phenethyl isothiocyanate (PEITC) on the postnatal growth and neurobehavioral development of rats. METHODS: Pregnant adult rats were randomly assigned to 4 groups, of which 3 groups were exposed to PEITC at doses of 15, 60 and 120 mg/kg respectively from the 7th to 16th day of gestation, and their F1 pups were observed the impact of PEITC on the age acquisition of two reflexes (cliff avoidance, surface righting) and sensuous function (auditory startle and olfactory discrimination), movement and coordination functions (forelimb hanging) and learning and memory (Y-maze test). F1 pups' brain tissues were taken and neuronal morphology changes were observed with pathology staining. RESULTS: Compared to the control group, 60 and 120 mg/kg groups exposed inuterus caused the F1 rat pups' cliff avoidance, surface righting and olfactory discrimination development delaying,and their learning and memory abilities were impaired. The increase to 0 -1 level in histological grades and decrease to 142 +/- 6.7 in neuronal density in the F1 pups of 120 mg/kg group were proved. CONCLUSION: PEITC exposure inuterus may impaire the F1 pups' neuro-behavior development and the abilities of learning, and the 15 mg/kg level of PEITC has no effects on developmental neurotoxicity and behavioral teratogenesis.
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