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  • Title: Synthesis and biological activity of 22-deoxo-23-oxa analogues of saponin OSW-1.
    Author: Maj J, Morzycki JW, Rárová L, Oklest'ková J, Strnad M, Wojtkielewicz A.
    Journal: J Med Chem; 2011 May 12; 54(9):3298-305. PubMed ID: 21438635.
    Abstract:
    Analogues of the potent cytotoxic saponin OSW-1 were prepared from the readily available steroidal 16β,17α,22-triol. The new 22-deoxo-23-oxa analogues of OSW-1 were screened against eight cancer cell lines and normal human fibroblasts. The analogues proved to be slightly less active than OSW-1 but also less toxic to normal cells. They induce concentration- and time-dependent apoptosis of mammalian cancer cells with caspase-3 activation.
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