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  • Title: MLL1/WDR5 complex in leukemogenesis and epigenetic regulation.
    Author: Wu M, Shu HB.
    Journal: Chin J Cancer; 2011 Apr; 30(4):240-6. PubMed ID: 21439245.
    Abstract:
    MLL1 is a histone H3Lys4 methyltransferase and forms a complex with WDR5 and other components. It plays important roles in developmental events, transcriptional regulation, and leukemogenesis. MLL1-fusion proteins resulting from chromosomal translocations are molecular hallmarks of a special type of leukemia, which occurs in over 70% infant leukemia patients and often accompanies poor prognosis. Investigations in the past years on leukemogenesis and the MLL1-WDR5 histone H3Lys4 methyltransferase complex demonstrate that epigenetic regulation is one of the key steps in development and human diseases.
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