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Title: Regulation of Foxo-dependent transcription by post-translational modifications. Author: Boccitto M, Kalb RG. Journal: Curr Drug Targets; 2011 Aug; 12(9):1303-10. PubMed ID: 21443461. Abstract: The Forkhead Box O (Foxo) proteins represent an evolutionarily conserved family of transcription factors that play an important role in regulating processes including metabolism, longevity, and cell death/survival. How is it that a single transcription factor can initiate such divergent cellular responses? We will review the evidence that specific patterns of post-translational modifications play a key role in directing Foxo into various transcriptional readouts. This regulation appears to take on a two tiered regulatory model; with a group of well defined post-translational modifications regulating nuclear localization and transcriptional activity while a second set of modifications regulate the transcriptional specificity of Foxo.[Abstract] [Full Text] [Related] [New Search]