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  • Title: PCL/PEG copolymeric nanoparticles: potential nanoplatforms for anticancer agent delivery.
    Author: Gou M, Wei X, Men K, Wang B, Luo F, Zhao X, Wei Y, Qian Z.
    Journal: Curr Drug Targets; 2011 Jul 01; 12(8):1131-50. PubMed ID: 21443476.
    Abstract:
    Nanotechnology provides researchers with new tools for cancer treatment. Biodegradable polymeric nanoparticles, as an advanced drug delivery system, have promising applications in cancer treatment. Poly(ε-caprolactone)/poly(ethylene glycol) (PCL/PEG) copolymers are biodegradable and amphiphilic, and show potential application in drug delivery. In recent years, PCL/PEG copolymeric nanoparticles, as a potential nanoplatform for anticancer agent delivery, received increasing attention. This paper reviews PCL/PEG copolymer nanoparticles for anticancer agent delivery, including overcoming water insolubility of hydrophobic drug, targeting chemotherapeutic drug to tumor, and delivering genes, vaccines, and diagnostic agents.
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