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  • Title: A quantum-dot based protein module for in vivo monitoring of protease activity through fluorescence resonance energy transfer.
    Author: Biswas P, Cella LN, Kang SH, Mulchandani A, Yates MV, Chen W.
    Journal: Chem Commun (Camb); 2011 May 14; 47(18):5259-61. PubMed ID: 21445447.
    Abstract:
    Here, we present a new generation of nanoscale probes for in vivo monitoring of protease activity by fluorescence resonance energy transfer (FRET). The approach is based on a genetically programmable protein module carrying a fluorescently labeled, protease-specific sequence that can self-assemble onto quantum dots. The protein module was used for real-time detection of human immunodeficiency virus type-1 protease (HIV-1 Pr) activity as well as quantitative assessment of inhibitor efficiency.
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