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  • Title: Anastrozole-related acute hepatitis with autoimmune features: a case report.
    Author: Inno A, Basso M, Vecchio FM, Marsico VA, Cerchiaro E, D'Argento E, Bagalà C, Barone C.
    Journal: BMC Gastroenterol; 2011 Mar 31; 11():32. PubMed ID: 21453541.
    Abstract:
    BACKGROUND: Two cases of acute hepatitis occurring during treatment with anastrozole have previously been reported, but the underlying mechanisms of liver injury are still uncertain. We report the case of anastrozole-related acute hepatitis with some autoimmune features. CASE PRESENTATION: A 70-year-old woman developed acute hepatitis associated with serum antinuclear antibodies during anastrozole treatment; after drug withdrawal, liver function parameters rapidly improved and serum auto-antibodies were no longer detectable. CONCLUSIONS: Anastrozole-induced hepatotoxicity is a very rare event. Drug-drug interactions or metabolically-mediated damage might be involved, with a possible role of individual susceptibility. Our report suggests that an immune-mediated mechanism may also be considered in anastrozole-related liver injury.
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