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  • Title: [HLA-associated predisposition to dilated cardiomyopathy].
    Author: Polianskaia IS, Alekseev LP, Chumburidze VB, Iurenev AP, Guniia MG, Dubov PB, Dolbin AG.
    Journal: Klin Med (Mosk); 1990 Jun; 68(6):30-3. PubMed ID: 2145467.
    Abstract:
    HLA-antigens grade I and II were studied by tissue typing in 60 Russians and 40 Georgians suffering from dilated cardiomyopathy (DCMP), and 40 Georgians with virus myocarditis. 267 test-donors Russians and 579 Georgians served as control. Markers of DCMP predisposition were found different for Russians and Georgians: DR4 (relative risk 2.96) and A11 (RR = 3.07), R12 (RR = 5.5), respectively. Georgians have a marker of resistance to DCMP--B35 (RR = 0.15). Antigen B12 marks a severe DCMP course in Georgians. Markers of virus myocarditis predisposition were distinct from those of DCMP: A1 (RR = 3.78) and B27 (RR = 3.62). This shows different etiology of the two diseases. The conclusion is made on nonidentical genetic markers of predisposition and resistance to the same disease in various populations.
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