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  • Title: Fasting blood glucose levels and the long-term incidence and progression of cataract -- the Blue Mountains Eye Study.
    Author: Kanthan GL, Mitchell P, Burlutsky G, Wang JJ.
    Journal: Acta Ophthalmol; 2011 Aug; 89(5):e434-8. PubMed ID: 21457484.
    Abstract:
    PURPOSE: To assess the associations between fasting blood glucose and the long-term incidence and progression of cataract. METHODS: A total of 3654 persons aged 49+ years were examined at baseline with fasting blood glucose measured, and 2454 re-examined after 5 and/or 10 years. Lens photographs from each visit were used to assess cataract incidence and progression. Associations between baseline fasting blood glucose and incidence and progression of cortical, nuclear and posterior subcapsular (PSC) cataract were assessed using discrete logistic regression and change-point models. RESULTS: After adjusting for potential confounders, baseline fasting blood glucose was associated with the 10-year incidence of cortical cataract with a threshold at blood glucose level of 6.0 mm (odds ratio [OR] 1.79, 95% confidence interval [CI] 1.25-2.57 for fasting glucose ≥6.0 mm compared to fasting glucose <6.0 mm). Each 1.0 mm increase in fasting glucose was also associated with higher 5-year progression of PSC (OR 1.25, 95% CI: 1.15-1.35), 10-year progression of cortical (OR 1.14, 95% CI: 1.01-1.27) and nuclear (OR 1.20, 95% CI: 1.01-1.43) cataract, with no thresholds detected. CONCLUSIONS: In this primarily nondiabetic older population, baseline fasting blood glucose was associated with the long-term incidence of cortical cataract and long-term progression of all three cataract subtypes.
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