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  • Title: Synthesis and antiproliferative activity of new cytotoxic azanaphthoquinone pyrrolo-annelated derivatives: Part II.
    Author: Shanab K, Schirmer E, Wulz E, Weissenbacher B, Lassnig S, Slanz R, Fösleitner G, Holzer W, Spreitzer H, Schmidt P, Aicher B, Müller G, Günther E.
    Journal: Bioorg Med Chem Lett; 2011 May 15; 21(10):3117-21. PubMed ID: 21458262.
    Abstract:
    A series of 6-azanaphthoquinone pyrrolo-annelated derivatives carrying different basic side chains have been synthesized. The antiproliferative activities of all compounds were evaluated on at least four different cell lines with Mitoxantrone as reference compound. Cytotoxic effects and DNA intercalation behavior were investigated.
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