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  • Title: Synthesis and cytotoxic evaluation of N-(4-methoxy-1H-benzo[d]imidazol-7-yl)-arylsulfonamide and N-aryl-(4-methoxy-1H-benzo[d]imidazol)-7-sulfonamide analogs of combretastatin A-4.
    Author: Zhou J, Zhang Y, Cui YW, Li ZM, Song HR, Dong JH, Chen XG, Xu BL.
    Journal: J Asian Nat Prod Res; 2011 Apr; 13(4):330-40. PubMed ID: 21462036.
    Abstract:
    Two series of novel benzoimidazole sulfonamides as combretastatin A-4 analogs were synthesized. The cytotoxicities of the title compounds were evaluated against five different cancer cell lines. Among the tested compounds, four compounds displayed cytotoxicities against the HCT8 cell line. Compound 6a has shown the strongest potency against the tested human tumor cell lines with an IC₅₀ value ranging from submicromolar to micromolar level.
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