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  • Title: Synthesis and antiproliferative activities of novel 5'-Schiff-base group substituted psoralen derivatives.
    Author: Chen CY, Sun JG, Huang ZZ, Kwok TT, Fung KP, Wu P, Liu FY.
    Journal: Yao Xue Xue Bao; 2011 Jan; 46(1):64-9. PubMed ID: 21462896.
    Abstract:
    It was found that psoralen derivative could perform a Friedel-Crafts acylation smoothly with acetic anhydride to give 5'-acetylpsoralen in a 73% yield. In the presence of boron trifluoride etherate, 5'-acetylpsoralen reacted with both aromatic amines and aliphatic amine smoothly to afford 5'-Schiff-base group substituted psoralen derivatives in 72%-92% yields. The novel synthetic method has the advantages of cheap materials, mild reaction conditions, good yields and high regioselectivity in the Friedel-Crafts acylation. Cell viability assay by MTT demonstrates that some of the psoralen derivatives 6 have antiproliferative activities.
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