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  • Title: Lung carcinoma with hypertrophic osteoarthropathy in a teenager.
    Author: Miller RE, Illing RO, Whelan JS.
    Journal: Rare Tumors; 2011 Mar 30; 3(1):e8. PubMed ID: 21464881.
    Abstract:
    Hypertrophic osteoarthropathy (HOA) characterised by arthralgia, clubbing and periosteal proliferation of long bones, is rarely encountered in children and adolescents. Whereas in adults over 80% of cases are associated with malignancy, in children the majority of cases are due to non-neoplastic causes such as cystic fibrosis, bilary atresia and congenital heart disease. Up to 5% of adults with lung cancer demonstrate signs of HOA. However, lung cancer is extremely uncommon in children and young people. Here we report a case of lung adenocarcinoma in an 18 year old male associated with HOA present both at diagnosis and at subsequent disease progression.
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