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  • Title: Preparation and efficacy of an inactivated subunit vaccine (NFUIBHK) against type 2 Herpes simplex virus infection.
    Author: Skinner GR, Williams DR, Buchan A, Whitney J, Harding M, Bodfish K.
    Journal: Med Microbiol Immunol; 1978 Nov 17; 166(1-4):119-32. PubMed ID: 214676.
    Abstract:
    A vaccine against Herpes simplex virus infection was prepared by Nonidet NP 40 and formalin treatment of a type 1, infected-cell extract; virus particles were removed by ultracentrifugation over sucrose. These procedures were not detrimental to the antigenic quality of the vaccine preparation. The vaccine afforded significant protection to experimental type 2 genital herpes virus infection in mice, as adjudged by clinical observations, cytopathological change, and virus yields.
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