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  • Title: Microbial mannosidation of bioactive chlorogentisyl alcohol by the marine-derived fungus Chrysosporium synchronum.
    Author: Yun K, Kondempudi CM, Choi HD, Kang JS, Son BW.
    Journal: Chem Pharm Bull (Tokyo); 2011; 59(4):499-501. PubMed ID: 21467683.
    Abstract:
    The biological transformation of the biologically active chlorogentisyl alcohol (1), isolated from the marine-derived fungus Aspergillus sp., was studied. Preparative-scale fermentation of chlorogentisyl alcohol with marine-derived fungus Chrysosporium synchronum resulted in the isolation of a new glycosidic metabolite, 1-O-(α-D-mannopyranosyl)chlorogentisyl alcohol (2). The stereostructure of the new metabolite obtained was assigned on the basis of detailed spectroscopic data analyses, chemical reaction, and chemical synthesis. Compounds 1 and 2 exhibited significant radical-scavenging activity against 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) with IC(50) values of 1.0 and 4.7 µM, respectively. The compounds 1 and 2 were more active than the positive control, L-ascorbic acid (IC(50), 20.0 µM).
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