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  • Title: Effects of s-allyl-L-cysteine on cell proliferation and neuroblast differentiation in the mouse dentate gyrus.
    Author: Nam SM, Yoo DY, Kim W, Yoo M, Kim DW, Won MH, Hwang IK, Yoon YS.
    Journal: J Vet Med Sci; 2011 Aug; 73(8):1071-5. PubMed ID: 21467757.
    Abstract:
    In this study, we investigated the effects of S-allyl-L-cysteine (SAC), a major sulfur-containing compound present in garlic, on Ki67- and doublecortin (DCX)-positive cells, which were used as a marker for cell proliferation and neuroblast differentiation, respectively, in the mouse dentate gyrus. SAC (300 mg/kg) was intraperitoneally administered to 8-week-old mice once a day for 3 weeks. The animals were then sacrificed at 11 weeks of age. SAC administration significantly increased Ki67-positive nuclei and DCX-immunoreactive neuroblasts in the subgranular zone of the dentate gyrus. Furthermore, serotonin 1A receptor (5-HT(1A)) levels in the hippocampus were also increased. These results suggest that SAC significantly increased cell proliferation and neuroblast differentiation by increasing 5-HT(1A) levels in the dentate gyrus.
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