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  • Title: (-)-Epigallocatechin gallate inhibits thyroid hormone-stimulated osteocalcin synthesis in osteoblasts.
    Author: Kato K, Otsuka T, Adachi S, Matsushima-Nishiwaki R, Natsume H, Kozawa O, Tokuda H.
    Journal: Mol Med Rep; 2011; 4(2):297-300. PubMed ID: 21468567.
    Abstract:
    It is recognized that catechin possesses beneficial properties for bone metabolism. We previously revealed that triiodothyronine (T₃)-activated p38 mitogen-activated protein (MAP) kinase, but not p44/p42 MAP kinase, is involved in the synthesis of osteocalcin in osteoblast-like MC3T3-E1 cells. In the present study, we investigated the effect of (-)-epigallocatechin gallate (EGCG), the predominant green tea polyphenol, on the synthesis of osteocalcin in MC3T3-E1 cells. EGCG significantly suppressed T₃-stimulated osteocalcin synthesis. The inhibitory effect of EGCG was dose-dependent in the range of 3 to 30 µM. On the other hand, T₃-induced phosphorylation of p38 MAP kinase was not affected by EGCG. EGCG profoundly inhibited T₃-stimulated transcriptional activity. These results strongly suggest that EGCG suppresses T3-stimulated osteocalcin synthesis upstream of the transcriptional level in osteoblast-like MC3T3-E1 cells.
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