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  • Title: Antimicrobial activity of a new combination system of benzimidazole and various azoles.
    Author: Ozkay Y, Tunalı Y, Karaca H, Işıkdağ I.
    Journal: Arch Pharm (Weinheim); 2011 Apr; 344(4):264-71. PubMed ID: 21469176.
    Abstract:
    In the present study a new series of benzimidazole derivatives bearing various (benz)azolylthio moieties were synthesized so as to investigate their antimicrobial activity. Structures of the target compounds (5a-5i) were confirmed by their IR, (1) H-NMR, ES-MS spectral data, and elemental analyses. The synthesized compounds (5a-5i) exhibited poor activity against bacterial strains. On the other hand, antifungal activity of the compounds against Candida species was very significant. Brine-Shrimp lethality assay was performed for determination of toxicity of the compounds. Compounds 5a, 5c, and 5d were evaluated as non-toxic in addition to their attractive antifungal activity. However, the other compounds (5b, e-i) in the series showed toxicity to different extents.
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