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  • Title: Gene and precursor structure of porcine C-type natriuretic peptide.
    Author: Tawaragi Y, Fuchimura K, Nakazato H, Tanaka S, Minamino N, Kangawa K, Matsuo H.
    Journal: Biochem Biophys Res Commun; 1990 Oct 30; 172(2):627-32. PubMed ID: 2146957.
    Abstract:
    Recently we isolated from porcine brain two related peptides, a 22-residue peptide (CNP-22) and its N-terminally elongated peptide (CNP-53; 53-residue), which belong to the third type of mammalian natriuretic peptide designated C-type natriuretic peptide family (CNP) (1,2). To elucidate the structure of their precursor form, we have now isolated the gene for this porcine CNP and prepared its cDNA from COS-1 cells transfected with the gene. Nucleotide sequence analyses have revealed that the gene consists of a least two exons and an intron and encodes the 126-residue CNP precursor (porcine prepro-CNP), in which a putative signal peptide and the CNP-53 sequence are located at the N- and C-terminus, respectively. The C-terminal cysteine codon of CNP-53 is directly followed by a termination codon, indicating that the C-terminus of porcine CNP is generated per se.
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