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  • Title: Flattened circadian cortisol rhythm in type 2 diabetes.
    Author: Lederbogen F, Hummel J, Fademrecht C, Krumm B, Kühner C, Deuschle M, Ladwig KH, Meisinger C, Wichmann HE, Lutz H, Breivogel B.
    Journal: Exp Clin Endocrinol Diabetes; 2011 Oct; 119(9):573-5. PubMed ID: 21472658.
    Abstract:
    INTRODUCTION: While altered cortisol concentrations have been observed in subjects with type 2 diabetes their circadian cortisol profile is unknown. PATIENTS AND METHODS: Using a cross-sectional design, we studied 63 ambulatory individuals with type 2 diabetes and 916 non-diabetic control subjects of the Cooperative Research in the Region of Augsburg (KORA)-F3 study. Circadian cortisol profiles were derived from saliva cortisol concentrations, determined on a regular weekday upon wake-up (F0), as well as ½ h (F½), 8 (F8) and 14 h (F14) after wake-up. RESULTS: Diabetic subjects exhibited a flattened circadian cortisol profile (rm-ANOVA: F[3,654]=3.41, p=0.02), with lower morning and higher afternoon and evening cortisol concentrations. CONCLUSION: We observed a flattened circadian cortisol rhythm in subjects with type 2 diabetes, providing evidence for a specific HPA system dysfunction.
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