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  • Title: [Role of serotonin receptors in the delta-opioid immunosuppression].
    Author: Cheĭdo MA, Idova GV.
    Journal: Ross Fiziol Zh Im I M Sechenova; 2010 Dec; 96(12):1234-40. PubMed ID: 21473110.
    Abstract:
    The present study indicates involvement of serotoninergic (5-HTergic) mechanisms in immunosuppression by DSLET (100 mkg/kg), a selective agonist of the delta2-opioid receptors, in CBA mice. 8-OH-DPAT (0.1 mg/kg), a selective agonist of the 5-HT(1A)-autoreceptors, WAY-100635 (1, 3 mg/kg) and ketanserin (1, 3 mg/kg), a selective antagonists of the postsynaptic 5-HT(1A)- and 5-HT(2A)-receptors, respectively, prevented immunosuppressive effect of DSLET. A possible differential role for 5-HT-receptors in delta-opioid immunosuppression is suggested.
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