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  • Title: Reversal of renovascular hypertension by antibodies specific for angiotensin-converting enzyme.
    Author: Markle RA, Sonnenblick EH, Conroy JM, Soffer RL.
    Journal: Proc Natl Acad Sci U S A; 1978 Nov; 75(11):5702-5. PubMed ID: 214795.
    Abstract:
    Goat antibodies developed against pure rabbit pulmonary angiotensin-converting enzyme (peptidyl dipeptidase, EC 3.4.15.1) were administered intravenously to rats with two-kidney Goldblatt hypertension and to normotensive animals. In the hypertensive model these antibodies were associated with a sustained, immune-dependent decrease of blood pressure to normal values. A smaller, but also immune-specific, reduction of blood pressure was observed in the normotensive group. The data suggest that heterologous antibody directed against angiotensin-converting enzyme may provide a biologically specific probe for examining the contribution of the renin-angiotensin system to normal and pathologic circulatory states.
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