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  • Title: Neurotoxicity induced by continuous infusion of quinolinic acid into the lateral ventricle in rats.
    Author: Yamada K, Fuji K, Nabeshima T, Kameyama T.
    Journal: Neurosci Lett; 1990 Oct 02; 118(1):128-31. PubMed ID: 2147984.
    Abstract:
    Acute intrastriatal injection of quinolinic acid (QA) caused a significant reduction of choline acetyltransferase (ChAT) and glutamic acid decarboxylase (GAD) activities as well as a decrease of the specific binding of [3H]hemicholinium-3. Pretreatment with MK-801 completely blocked the QA-induced neurotoxicity. Continuous infusion of QA into the lateral ventricle resulted in a reduction of hippocampal and cortical ChAT activities while GAD activities were unchanged. These results suggest that continuous infusion of QA into the lateral ventricle could be a useful technique for the study of chronic neurodegenerative diseases including Alzheimer's disease.
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