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  • Title: Two new lignans and anti-HBV constituents from Illicium henryi.
    Author: Liu JF, Jiang ZY, Geng CA, Zhang Q, Shi Y, Ma YB, Zhang XM, Chen JJ.
    Journal: Chem Biodivers; 2011 Apr; 8(4):692-8. PubMed ID: 21480515.
    Abstract:
    Two new lignans, dihydrodehydrodiconiferyl alcohol 9-O-β-D-(3″-O-acetyl)-xylopyranoside (1) and threo-4,9,9'-trihydroxy-3,3'-dimethoxy-8-O-4'-neolignan 7-O-α-rhamnopyranoside (2) were isolated from Illicium henryi, together with ten known compounds, 3-12. Their structures were elucidated by extensive spectroscopic analyses. The anti-hepatitis B virus (anti-HBV) activity of compounds 1-12 inhibiting HBV surface antigen (HBsAg) and HBV e antigen (HBeAg) secretion on Hep G2.2.15 cell line was evaluated. (-)-Dihydrodehydrodiconiferyl alcohol (4) showed moderate inhibitory activity on both HBsAg and HBeAg secretion with IC(50) values of 0.06 and 0.53 mM, respectively.
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