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  • Title: Synthesis of 5(6)-dihydro-OSW-1 analogs bearing three kinds of disaccharides linking at 15-hydroxy and their antitumor activities.
    Author: Guan Y, Zheng D, Zhou L, Wang H, Yan Z, Wang N, Chang H, She P, Lei P.
    Journal: Bioorg Med Chem Lett; 2011 May 15; 21(10):2921-4. PubMed ID: 21482468.
    Abstract:
    In order to study the SAR of 5(6)-dihydro-OSW-1, eight 15(α)β-O-glycosyl analogs (26-33) carrying three kinds of disaccharides including [β-d-Xylp-(1-3)-α-l-Arap], [β-d-Xylp-(1-4)-α-l-Arap] and [α-l-Rhap-(1-2)-(α)β-d-Glcp] were designed and synthesized. Their in vitro antitumor activities were tested by the standard MTT assay which disclosed that compound 33 (IC(50)=0.28-0.52 μM) showed potential antitumor activities.
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