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  • Title: The effect of hydroxyapatite-coated titanium fiber web on human osteoblast functional activity.
    Author: Hirota M, Hayakawa T, Ametani A, Kuboki Y, Sato M, Tohnai I.
    Journal: Int J Oral Maxillofac Implants; 2011; 26(2):245-50. PubMed ID: 21483876.
    Abstract:
    PURPOSE: The aim of this study was to evaluate human osteoblast activity on thin hydroxyapatite (HA)-coated three-dimensional scaffolds made of titanium fiber web. MATERIALS AND METHODS: A thin HA film was coated on a titanium fiber web by the molecular precursor method. Human osteoblasts were disseminated onto the uncoated and HA-coated titanium fiber web, and osteoblast activity was observed at days 3, 7, 14, and 21 of culture. RESULTS: Proliferation activities of osteoblasts were significantly higher in the uncoated titanium fiber web. Osteoblasts in the uncoated titanium fiber web showed a typical expression pattern, but those in the HA-coated titanium fiber web showed rapid osteocalcin expression and calcification at an early stage of culture. Moreover, osteocalcin expression per osteoblast was significantly higher in the HA-coated group. CONCLUSION: These results suggest that HA coating with the molecular precursor method accelerated osteoblast functional activity.
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