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  • Title: Malformation spectra and embryolethality following intraamniotic administration of glucocorticoids in the chick embryo.
    Author: Kosar K.
    Journal: Anat Anz; 1990; 171(3):211-7. PubMed ID: 2148465.
    Abstract:
    The effects of a natural hormone hydrocortisone and of the synthetic corticoids dexamethasone and triamcinolone on several morphogenetic systems were investigated in 2, 3, 4 and 5 day-old chick embryos. Embryotoxic doses of the glucocorticoids were administered subgerminally on day 2, and intraamniotically on days 3, 4 and 5 of incubation. On the basis of morphological analysis of embryos performed on day 8 the malformation spectrum was determined, which shows nearly identical characteristics in all the corticoids under study. Morphogenetic systems of the body wall and face were affected most frequently; the eye only to a little extent, and the brain only rarely. No malformations of the limbs, trunk and heart were found. Embryolethal effect was observed approximately in a quarter of embryos of the individual experimental groups.
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