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  • Title: Cellular analysis of long-term habituation of the gill-withdrawal reflex of Aplysia californica.
    Author: Castellucci VF, Carew TJ, Kandel ER.
    Journal: Science; 1978 Dec 22; 202(4374):1306-8. PubMed ID: 214854.
    Abstract:
    Long-term habituation training in Aplysia californica produces a profound depression in the efficacy of synaptic transmission between mechanoreceptor neurons and gill motor neurons. This depression persists for more than 3 weeks. Thus a critical synaptic site for plasticity underlying long-term habituation is the same as that for short-term habituation. For this simple form of learning, short- and long-term memory share a common locus and aspects of a common mechanism: synaptic depression.
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