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  • Title: Prenylated Polyhydroxy-p-terphenyls from Aspergillus taichungensis ZHN-7-07.
    Author: Cai S, Sun S, Zhou H, Kong X, Zhu T, Li D, Gu Q.
    Journal: J Nat Prod; 2011 May 27; 74(5):1106-10. PubMed ID: 21486068.
    Abstract:
    Six new prenylated polyhydroxy-p-terphenyl metabolites, named prenylterphenyllins A-C (1-3) and prenylcandidusins A-C (5-7), and one new polyhydroxy-p-terphenyl with a simple tricyclic C-18 skeleton, named 4''-dehydro-3-hydroxyterphenyllin (4), were obtained together with eight known analogues (8-15) from Aspergillus taichungensis ZHN-7-07, a root soil fungus isolated from the mangrove plant Acrostichum aureum. Their structures were determined by spectroscopic methods, and their cytotoxicity was evaluated using HL-60, A-549, and P-388 cell lines. Compounds 1 and 8 exhibited moderate activities against all three cell lines (IC50 1.53-10.90 μM), whereas compounds 4 and 6 displayed moderate activities only against the P-388 cell line (IC50 of 2.70 and 1.57 μM, respectively).
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