These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Hand-Schüller-Christian disease with occult diabetes insipidus, cardiac failure and renal dysfunction.
    Author: Kimura T, Ota K, Shoji M, Inoue M, Sato K, Ohta M, Yamamoto T, Endo K, Osaki H, Aoyama H.
    Journal: Jpn J Med; 1990; 29(4):405-10. PubMed ID: 2148780.
    Abstract:
    A 60-year-old man was diagnosed as Hand-Schüller-Christian disease due to the triad of exophthalmus, decalcification of the bone, and diabetes insipidus. He had xanthogranuloma on the face and a nuchal region, and unusual complications of ADH-resistant diabetes insipidus due to renal dysfunction, and chronic cardiac failure. Urine osmolality was hypotonic, but urine volume was within the normal limit, despite the presence of central diabetes insipidus. Hypophyseal, adrenal and thyroid function were not remarkable. The skin biopsy showed the infiltration of eosinophilic granuloma cells. Treatment with vincristine was effective to regress the xanthogranuloma. Diabetes insipidus was not treated because of the absence of polyuria and polydipsia.
    [Abstract] [Full Text] [Related] [New Search]