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  • Title: Drug discovery in enteroviral infections.
    Author: Chen TC, Shih SR.
    Journal: Infect Disord Drug Targets; 2011 Jun; 11(3):337-45. PubMed ID: 21488833.
    Abstract:
    Enteroviruses (EVs) are common and significant human pathogens in Asia. EV infections can cause a wide spectrum of acute diseases, including CNS complications. These EV infection-related CNS syndromes include acute flaccid paralysis, aseptic meningitis, encephalitis, and even death. Currently, there is no vaccine available for most EVs except for poliovirus; furthermore, there is a lack of clinical antiviral drugs for treating EV-related infections. These shortages reveal the need to develop potent compounds for treating enteroviral infections. This study summarizes the development of drugs for EV-related infections based on molecular targets blocking various steps in the viral replication cycle.
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