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  • Title: Antibody response to preS1 in hepatitis-B-virus-induced liver disease and after immunization.
    Author: Coursaget P, Buisson Y, Bourdil C, Yvonnet B, Molinié C, Diop MT, Chiron JP, Bao O, Diop-Mar I.
    Journal: Res Virol; 1990; 141(5):563-70. PubMed ID: 2148981.
    Abstract:
    Antibodies to the pre-S1-encoded sequence of hepatitis B virus (HBV) envelope were detected by ELISA using a synthetic peptide analogue of preS1 proteins, in different groups of HBV-infected subjects and also in hepatitis B vaccine recipients. Such antibodies were specifically found in only 1% of HBsAg chronic carriers including patients with cirrhosis and primary liver cancer. Anti-preS1 were detected in patients with acute hepatitis; in 13% of the HBsAg+ sera obtained before recovery and in 37% of the sera obtained after recovery. Anti-preS1 antibodies were detected in recipients of a plasma-derived vaccine, but not in those receiving a recombinant vaccine. The results indicate that anti-preS1 is an earlier serum marker of HBV clearance than anti-preS2 and anti-S antibodies.
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