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  • Title: [Effect of potassium orotate on metabolism in chickens under different provision with vitamin D3].
    Author: Kotsiuruba AV, Kokunin VA, Vendt VP, Tkachuk AM.
    Journal: Ukr Biokhim Zh (1978); 1978; 50(5):641-8. PubMed ID: 214921.
    Abstract:
    Vitamin D3 induction of the vitamin-D3-dependent proteins biosynthesis and certain indexes characterizing the rachitic state in animals were studied as affected by potassium orotate. Introduction of potassium orotate to the rachitogenic diet in combination with vitamin D3 is shown to normalize the processess of bone mineralization and to increase intensity of chicken growth. In duodenum mucosa with rachitis orotate normalizes the activity of alkaline phosphatase, raises the content of calcium-binding protein and stimulates the latter formation after administration of vitamin D3; orotate favours redistribution of the purine and pyrimidine nucleotides content. Radioactive orotic acid is subjected to intensive metabolism in mucosa and is converted to nucleotides of pool and RNA.
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