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  • Title: Discovery of pyrimidine carboxamides as potent and selective CCK1 receptor agonists.
    Author: Wang L, Hubert JA, Lee SJ, Pan J, Qian S, Reitman ML, Strack AM, Weingarth DT, MacNeil DJ, Weber AE, Edmondson SD.
    Journal: Bioorg Med Chem Lett; 2011 May 15; 21(10):2911-5. PubMed ID: 21493064.
    Abstract:
    A series of six-membered heterocycle carboxamides were synthesized and evaluated as cholecystokinin 1 receptor (CCK1R) agonists. A pyrimidine core proved to be the best heterocycle, and SAR studies resulted in the discovery of analog 5, a potent and structurally diverse CCK1R agonist.
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