These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Behavioral mechanisms for the anorectic action of the serotonin (5-HT) uptake inhibitor sertraline in rats: comparison with directly acting 5-HT agonists.
    Author: Simansky KJ, Vaidya AH.
    Journal: Brain Res Bull; 1990 Dec; 25(6):953-60. PubMed ID: 2149668.
    Abstract:
    The 5-HT uptake inhibitor, sertraline (5-40 mumol/kg, IP) reduced the volume of milk consumed by food-deprived rats during a 30-min test (ID50 = 12 mumol/kg). Observations using a time-sampling method revealed that sertraline shortened meal duration (ID50 = 14 mumol/kg) by decreasing feeding and increasing resting without altering nonfeeding activity or the overall sequence of behavior that characterizes normal satiety. In separate experiments, analysis of videotapes demonstrated that sertraline (10 mumol/kg) decreased not only the time that rats fed but also their actual rate of intake. In comparison, doses of the direct 5-HT agonists, mCPP (1-[3-chlorophenyl]piperazine), RU 24969 (5-methoxy-3-[1,2,3,6-tetrahydropyridin-4-yl]-1H-indole), and DOI (1-[2,5-dimethoxy-4-iodophenyl]-2-amino-propane) that produced similar anorectic effects altered either feeding time or rate but not both. DOI also disrupted the continuity of feeding and the 5-HT agonist, 8-OH-DPAT (8-hydroxy-di-N-propylamino tetralin) produced marked stereotypy at anorectic doses. Together, these results imply that stimulating a number of different serotonergic mechanisms can reduce food intake in rats. Sertraline appears to accelerate the onset of normal satiety, presumably by enhancing physiological actions of endogenous 5-HT.
    [Abstract] [Full Text] [Related] [New Search]