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  • Title: Antitumor activities of an anthraquinone fraction isolated from in vitro cultures of Ophiorrhiza rugosa var decumbens.
    Author: Raveendran VV, Vijayan FP, Padikkala J.
    Journal: Integr Cancer Ther; 2012 Jun; 11(2):120-8. PubMed ID: 21498471.
    Abstract:
    The biological effects of the anthraquinone fraction (AQf) isolated from in vitro cultures of Ophiorrhiza rugosa Wall. var decumbens (Rubiaceae) were evaluated. AQf showed differential activity on reactive oxygen species; it mediated the generation of superoxide radical and inhibited hydroxyl radical and lipid peroxidation. No considerable nitric oxide scavenging activity was observed for AQf. The AQf induced 50% cytotoxicity in Ehrlich ascites carcinoma and Dalton's lymphoma ascites at concentrations of 130 and 60 µg/mL, respectively. It effectively reduced the inflammation induced by carrageenan in mice. An AQf concentration of 200 mg/kg body weight reduced solid tumor progression in mice. It also prolonged the life span of ascites tumor-bearing mice compared with control mice.
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