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  • Title: Multiple selenocysteine content of selenoprotein P in rats.
    Author: Motchnik PA, Tappel AL.
    Journal: J Inorg Biochem; 1990 Nov; 40(3):265-9. PubMed ID: 2149860.
    Abstract:
    Partially purified selenoprotein P from rat plasma was digested with either trypsin, endoprotease Lys-C, or endoprotease Arg-C and analyzed by high pressure liquid chromatography and sodium dodecyl sulfate polyacrylamide gel electrophoresis. Several 75Se-labeled peptides were detected. The moles of selenium in selenoprotein P were estimated based on the 75Se content of the 75Se-labeled peptide fragments. Using this method, selenoprotein P was shown to contain approximately 9 moles of selenium. This is the first report of a selenoprotein containing more than one selenium per polypeptide. These findings support the proposed function of this protein in selenium transport.
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